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KMID : 0614620020400020137
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Korean Journal of Gastroenterology
2002 Volume.40 No. 2 p.137 ~ p.141
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A Case of Acute Intestinal Graft Versus Host Disease
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강정묵/Jung Mook Kang
양종인/민병훈/우상명/김병관/김주성/정현채/송인성/Jong In Yang/Byung Hoon Min/Sang Myeong Woo/Byeong Gwan Kim/Joo Sung Kim/Hyun Chae Jung/In Sung Song
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Abstract
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Acute graft versus host disease (GVHD) is the leading cause of morbidity and mortality after bone marrow transplantation. Target organs of acute GVHD are the skin, intestinal tract, and liver. Intestinal involvement in acute GVHD varies from
anorexia,
vomiting, abdominal pain, and diarrhea to massive gastrointestinal bleeding. These symptoms are not specific for acute GVHD. Thus, the diagnosis can be very difficult to establish on clinical grounds. We experienced a patient with bloody diarrhea
successfully diagnosed as having acute intestinal GVHD on sigmoid colon biopsy. Endoscopic appearance of the rectum and sigmoid colon of patient with acute GVHD is presented. A 20-year-old man with chronic myelogenous leukemia suffered from
bloody
diarrhea 3 months after unrelated bone marrow transplantation. Sigmoidoscopy showed multiple erosion with spontaneous bleeding. The section of the biopsy specimen were compatible with acute GVHD. A follow-up endoscopy after steroid therapy showed
gradual healing of the lesions.
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